![]() Today, scientists know that Flemming had successfully distinguished chromosomes in the interphase portion of the cell cycle from chromosomes undergoing mitosis, or the portion of the cell cycle during which the nucleus divides (Figure 1). (We still use the word "chromatin" today, albeit in a more biochemical sense to refer to complexes of nuclear DNA and protein.) Specifically, in some cells, chromatin appeared as an amorphous network, although in other cells, it appeared as threadlike bodies that Flemming named "mitosen." Based on his observations, Flemming had the insight to propose that chromatin could undergo reversible transformations in cells. In his pioneering studies of mitosis, Flemming noted that the nuclear material, which he named " chromatin" for its ability to take up stains, did not have the same appearance in all cells.
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